N evertheless, some studies suggest matters of concern. For the mother, these include increased maternal infection and suppression of the maternal hypothalamic-pituitary-adrenal axis. Fetal/neonatal effects include decreased somatic and brain growth, adrenal suppression, neonatal sepsis, chronic lung disease, and mortality. No consistent effect on intraventricular hemorrhage was apparent from the available data. Although no increase in the incidence of cerebral palsy was noted, neurodevelopmental followup studies suggest an increase in psychomotor delay and behavioral problems. Concern about the effects of repeated corticosteroids on the central nervous system is heightened by the fact that randomized controlled trials of postnatal corticosteroids have found adverse neurologic effects in infants of gestational age similar to those treated in utero.
I’m not 100% on dates etc. Of my last period, but they are usually regular and around the same time as my partners mother (sounds strange but only way I can describe it) well last week she had hers and I usually start the same day or the day after. I haven’t had my periods but I am sexually active and we havent used protection. I came off birth control in January and my periods have still been regular since. But the last 2 weeks my nipples have been really tender and sore to touch and feel and look slightly bigger. It sometimes hurts having sex, and I’m bloated. Ive also been tired a lot more than usual and out of breath so easily. I’ve been waking through the night up to 4 times a night either needing a drink or to pee, this doesn’t happen often, its only usually when I’m ill but I’m not ill. I’ve been thirsty a lot and needing to pee a lot as well, and its always a lot of pee and I can’t hold it long at all. I’ve been feeling sick as well, mostly in the mornings and at night. I started bleeding tonight, but its not a lot at all like its a tiny amount and nothing like my periods which are usually heavy, cramping is really bad to the point I’m doubled over in agony and can barely walk far. I haven’t took a test yet as I haven’t really got the money to buy one at the minute. Is there a chance I could be pregnant? Or am I over reacting?
Results One patient from the corticosteroid group was excluded from analyses because of consent withdrawal. There were 229 nonresponders to the corticotropin test (placebo, 115; corticosteroids, 114) and 70 responders to the corticotropin test (placebo, 34; corticosteroids, 36). In nonresponders, there were 73 deaths (63%) in the placebo group and 60 deaths (53%) in the corticosteroid group (hazard ratio, ; 95% confidence interval, -; P = .02). Vasopressor therapy was withdrawn within 28 days in 46 patients (40%) in the placebo group and in 65 patients (57%) in the corticosteroid group (hazard ratio, ; 95% confidence interval, -; P = .001). There was no significant difference between groups in responders. Adverse events rates were similar in the 2 groups.