Corticosteroid mechanism of action in psoriasis

"Axis Recovery"

  • Slow reduction in dose over extended period of time
  • change dose rate every 3-4 weeks, change to EOD for first reduction
  • No ACTH (maintains negative feedback on hypothalamus)
  • Remember extra pred. for "stress"
  • Daily replacement therapy
    • Prednisone or prednisolone preferred
    • 1 mg/kg of hydrocortisone activity each day (dog)
    • - mg/kg prednisone, prednisolone "normal" secretion rate not known for other species
  • "Stressful" Situations
    • additional prednisone or prednisolone
Anti-inflammatory and Anti-immunologic Therapy Steroids are potent drugs for interrupting events triggered at the cell membrane (prostaglandins, phospholipase, etc.), and cell mediated immunity (antigen recognition, cell migration, etc.)

Persons who are using drugs that suppress the immune system (., corticosteroids) are more susceptible to infections than healthy individuals. Chickenpox and measles , for example, can have a more serious or even fatal course in susceptible children or adults using corticosteroids. In children or adults who have not had these diseases or been properly immunized, particular care should be taken to avoid exposure. How the dose, route, and duration of corticosteroid administration affect the risk of developing a disseminated infection is not known. The contribution of the underlying disease and/or prior corticosteroid treatment to the risk is also not known. If a patient is exposed to chickenpox, prophylaxis with varicella zoster immune globulin (VZIG) may be indicated. If a patient is exposed to measles, prophylaxis with pooled intramuscular immunoglobulin ( IG ) may be indicated (see the respective package inserts for complete VZIG and IG prescribing information). If chickenpox or measles develops, treatment with antiviral agents may be considered.

Corticosteroid mechanism of action in psoriasis

corticosteroid mechanism of action in psoriasis

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