Two published randomized controlled trials have reported on significant reductions in disease activity in patients with ankylosing spondylitis and other spondyloarthropathies who were treated with infliximab. Spondyloarthropathy (literally arthritis of the spine) may be associated with ankylosing spondylitis, Reiter's syndrome, reactive arthritis, psoriatic arthritis, and inflammatory bowel disease, or may be idiopathic (undifferentiated spondyloarthropathy). Van den Bosch et al (2002) reported on a 12-week long clinical study involving forty patients with active spondyloarthropathy who were randomly assigned to receive an intravenous loading dose (weeks 0, 2, and 6) of 5 mg/kg infliximab or placebo. Both patient and physician global assessments of disease activity on a visual analog scale improved significantly in the infliximab group compared with the baseline value, with no improvement in the placebo group. As early as week 2 and sustained up to week 12, there was a highly statistically significant difference between the values for these 2 endpoints in the infliximab versus the placebo group. In most of the other assessments of disease activity (laboratory measures, assessments of specific peripheral and/or axial disease), significant improvements were observed in the infliximab group compared with the baseline value and compared with placebo. There was 1 severe drug-related adverse event, in which a patient developed disseminated tuberculosis.
We too have been fighting for 18mths to have someone take notice of ours son’s condition. We have been told on so many occasions it is nothing…until we went to the ED again on the weekend and they bothered to run bloods and they realised how sick he was.
His fever was masked with ibuprofen when we first went in but after 9 hours in the ED his fever went crazy and finally they realised what we go through for 3 days every month.
We have been referred to rheumatologist and should see him in May hopefully.
I am just pleased to finally have some sort of diagnosis for our son and to have now found this blog which makes us feel a little less alone with our situation.
Author John Green writes books related to social justice. A couple of days ago, some social justice bloggers who disagreed with his perspective decided that a proportional response was to imply he was a creep who might sexually abuse children. Green was somewhat put out by this, and said on his Tumblr that he was “tired of seeing the language of social justice – important language doing important work – misused as a way to dehumanize others and treat them hatefully” and that he thought his harassers “were not treating him like a person”.