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G protein–coupled receptors (GPCRs) are a family of integral transmembrane proteins that possess seven transmembrane domains and are linked to a heterotrimeric G protein . With nearly 800 members, this is the largest family of membrane proteins and receptors in mammals. Counting all animal species, they add up to over 5000.  Mammalian GPCRs are classified into 5 major families: rhodopsin-like , secretin-like , metabotropic glutamate , adhesion and frizzled / smoothened , with a few GPCR groups being difficult to classify due to low sequence similarity, . vomeronasal receptors .  Other classes exist in eukaryotes, such as the Dictyostelium cyclic AMP receptors and fungal mating pheromone receptors .