When corticosteroids are taken as a medication, they can suppress the normal secretion of corticosteroids from the adrenal gland. If the corticosteroid medication is given over a very long time, it may cause the adrenal gland to no longer function effectively. It may take months to years for this gland to recover completely, long after use of a corticosteroid medication has been discontinued. The daily secretion of corticosteroids is essential to remaining healthy, particularly when the body is under physical stress (. severe illness or infection, surgery, acute asthmatic symptoms, or physical trauma). For example, if you become ill and your asthma worsens, the body normally responds to this physical stress by secreting up to 5 to 10 times the usual amount of natural corticosteroids. In addition, the adrenal gland's response to stress is also required for other important body functions.
PLACENTAL TROPHOBLAST DEVELOPMENT AND VASCULARIZATION During human and nonhuman primate pregnancy, the placenta simultaneously accesses the maternal blood and develops a vascular network for the transport of nutrients to and waste products from the fetus across the syncytiotrophoblast to ensure fetal growth and development. Both processes depend on the ability of the primordial stem-cell cytotrophoblasts to take either the villous pathway where they remain in the fetal compartment and differentiate morphologically into the syncytiotrophoblast or the extravillous pathway where they proliferate, aggregate into cell columns of the anchoring villi, and invade the endometrial stroma (Fig. 6). 105 The syncytiotrophoblast covers the floating chorionic villi that become highly vascularized, whereas the extravillous cytotrophoblasts infiltrate the walls of the spiral arterioles to facilitate the process of placentation.
Immunotherapy not only can suppress the inflammation of glomeruli like general treatment, but also can correct immune dysfunction and eliminate the antibody and antigen complexes caused by activities of immune system. Once the immune complexes are eliminated, if there is no new complexes forming, the inflammation in kidneys will not recure. If immune system is not corrected, no more abnormal activity of immune system will happen. If so, no pathological immune complexes will form. Thereby, steroid-dependent nephrotic syndrome will be controlled effectively without relapse.