The probabilities of success at 3 years for trabeculotomy for steroid-induced glaucoma vs trabeculotomy for POAG was % vs % for criterion A (P = .0008) and % vs % for criterion B (P < .0001), respectively. At 3 years, the success of trabeculotomy for steroid-induced glaucoma was comparable to trabeculectomy for steroid-induced glaucoma for criterion A (%; P = .3636), but lower for criterion B (%; P = .0352). Prognostic factors for failure of trabeculotomy for steroid-induced glaucoma were previous vitrectomy (relative risk [RR] = ; P = .0452 on criterion A, RR = ; P = .0360 for criterion B) and corticosteroid administration other than ocular instillation (RR = ; P = .0352 for criterion B).
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High doses of vitamin C were successfully used to lower intraocular eye pressure in one study on human subjects with chronic open-angle glaucoma. IV doses were in the range of 1 g/kg of body weight, oral doses (ascorbate) were half that – 500mg/kg of body weight. After a one time dose eye pressure decreased dramatically at 2 hours and at 4-5 hours. The drop in pressure lasted on average 8 hours. The higher the initial pressure was, the more it dropped. For example, the initial pressures of 50-69 mmHG dropped 16 mmHG at 2 hours and 25 mmHG at 4-5 hours. The pressures in the eye with normal IOP dropped mmHG.