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Ultimately, only a brain biopsy or autopsy can reveal the spongelike damage in the brain and confirm a CJD diagnosis, according to the NIH. The brain of a vCJD patient shows microscopic prion protein plaques circled by a halo of holes (like a daisy) known as "florid plaques." These are rarely seen in classic CJD patients, according to the CDC . Since a correct diagnosis of CJD would not help the patient or reverse the course of the disease, a brain biopsy is often discouraged unless it's needed to rule out other possible mental disorders.

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