According to researchers from the Netherlands, “ Rheumatoid arthritis (RA) is a heterogeneous disease with unknown cause. “ [iii] Differences in genetic expressions of RA patients were seen by these researchers lending some credence to a genetic link to sub-types of RA. In an earlier study of the genetics of RA in 1989, researchers found a gene called HLA-DR was found in 83% of 149 patients with classical or definite RA. [iv] But no explanation is given for the 17% of RA patients who did not show the gene. In 2010, a group of researchers found four genetic sub-types of RA. [v] Japanese scientists found genetic differences at the molecular level. They stated, “ Data from genome-wide screening, transcriptional profiling, and animal models indicate that RA consists with heterogeneous disease subsets .” [vi] Some researchers even found different emotional responses in RA patients. [vii]
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